Anti- OSBPL3 Antibody | FNab06021

Anti- OSBPL3 Antibody | FNab06021 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324) . Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204) . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204) . With VAPA, may regulate ER morphology (PubMed:16143324) . Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267) . Binds to phosphoinositides with preference for PI (3, 4) P2 and PI (3, 4, 5) P3 (PubMed:16143324) . Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193) .

Immunogen: oxysterol binding protein-like 3

synonyms: KIAA0704, ORP3, OSBP3

Molecular weight (observed) : 101 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism