Anti-PAD4 Polyclonal Antibody | A2324

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.

A2324 | Anti-PAD4 Polyclonal Antibody DataSheet

Antibody Target: Human PAD4

Target Alternative Name: Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4

Tag Line: Protein arginine deiminase associated with rheumatoid arthritis

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human Rat

Immunogen Sequence: Recombinant full length protein of human PAD4

Accession #: Q9UM07

Gene ID: 23569

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide

Purification: Immunogen affinity chromatography

Application: Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE