26
Anti-PD-L1 (Durvalumab), Human IgG1 Antibody | A2109
- SKU:
- 26-A2109-100-GEN
- Availability:
- Usually shipped in 5 working days
Description
The research-grade biosimilar is a human IgG1 monoclonal antibody that is produced by recombinant DNA technology in CHO cells. The antibody is a potent antagonist of programmed cell death-ligand 1 (PD-L1) function. It inhibits the interaction of PD-L1 with PD-1 and CD80 and activates T-lymphocytes to kill cancer cells. The monoclonal antibody does not cause antibody-dependent cellular cytotoxicity. The original monoclonal antibody is approved by the FDA for the treatment of metastatic urothelial carcinoma and in combination with etoposide, carboplatin, or cisplatin for extensive-stage small cell lung cancer (ES-SCLC)
A2109 | Anti-PD-L1 (Durvalumab), Human IgG1 Antibody DataSheet
Antibody Target: PD-L1
Target Alternative Name: PDL1, PD-L1, PD L1, B7-H, B7H1, B7-H1, CD274, PDCD1L1, B7 homolog 1, PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1
Tag Line: Human IgG1 monoclonal antibody that blocks the interaction of PD-L1 with PD-1 and CD80 and promotes normal immune response to attack tumor cells
Category: Primary antibody
Host: CHO cells
Isotype: Human IgG1, kappa
Species Reactivities:
Immunogen Sequence: Durvalumab
Accession #: DB11714
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: Lot specific
Formulation: In PBS buffer, pH 7.2
Purification:
Application: HTRF assay
Positive Control:
Application And Usages: HTRF assay
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Size: |
100 ug |
Storage Condition: |
4°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |