BW
Anti-PSMA7 monoclonal Antibody | MB62380
- SKU:
- BW-MB62380
- Availability:
- Usually ships in 5 working days
Description
Anti-PSMA7 monoclonal Antibody | MB62380 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human, Mouse, Rat
Application: FC, WB
Application Range: WB 1:500, IHC 1:50, Flow 1:100
Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.
Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Specificity: proteasome subunit alpha 7
Molecular Weight: 27.9 kDa (Predicted)
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: C6; HEL-S-276; HSPC; RC6-1; XAPC7
Immunogen: Full length human recombinant protein of human PSMA7 (NP_002783) produced in HEK293T cell.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway: N/A