Anti- RBBP6 Antibody | FNab07152

Anti- RBBP6 Antibody | FNab07152 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979) . May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity) . Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359) .

Immunogen: retinoblastoma binding protein 6

synonyms: P2PR, PACT, RBQ1

Molecular weight (observed) : 200 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Immunology, Metabolism