710
Anti- REDD1 specific Antibody | FNab07228
- SKU:
- 710-FNab07228-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- REDD1 specific Antibody | FNab07228 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function:Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1) . Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity) . Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity) . Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.
Immunogen: DNA-damage-inducible transcript 4
synonyms: HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, REDD-1, REDD1, RTP801, DDIT4
Molecular weight (observed) : 35 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200
Research Area: Epigenetics, Immunology, Cardiovascular