Anti- REDD1 specific Antibody | FNab07228

Anti- REDD1 specific Antibody | FNab07228 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function：Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1) . Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity) . Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity) . Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.

Immunogen: DNA-damage-inducible transcript 4

synonyms: HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, REDD-1, REDD1, RTP801, DDIT4

Molecular weight (observed) : 35 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200

Research Area: Epigenetics, Immunology, Cardiovascular