Anti- RUNX1T1 Antibody | FNab07535

Anti- RUNX1T1 Antibody | FNab07535 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Can repress transactivation mediated by TCF12 (PubMed:16803958) . Acts as a negative regulator of adipogenesis (By similarity) . The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588) .

Immunogen: runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

synonyms: AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Molecular weight (observed) : 70-75 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IF

Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200

Research Area: Metabolism