710
Anti- RUNX2 Antibody | FNab07536
- SKU:
- 710-FNab07536-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- RUNX2 Antibody | FNab07536 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity) . Inhibits KAT6B-dependent transcriptional activation.
Immunogen: runt-related transcription factor 2
synonyms: AML3, CBFA1, OSF2, PEBP2A
Molecular weight (observed) : 70 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:200-1:2000
Research Area: Stem Cells, cancer, Neuroscience, Developmental biology