Anti- RUNX2 Antibody | FNab07536

Anti- RUNX2 Antibody | FNab07536 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity) . Inhibits KAT6B-dependent transcriptional activation.

Immunogen: runt-related transcription factor 2

synonyms: AML3, CBFA1, OSF2, PEBP2A

Molecular weight (observed) : 70 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:200-1:2000

Research Area: Stem Cells, cancer, Neuroscience, Developmental biology