710
Anti- SATB2 Antibody | FNab07616
- SKU:
- 710-FNab07616-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SATB2 Antibody | FNab07616 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Immunogen: SATB homeobox 2
synonyms: DNA binding protein SATB2, KIAA1034, SATB homeobox 2, SATB2
Molecular weight (observed) : 83 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IP
Recomended Dillution : WB: 1:500 - 1:2000
Research Area: Neuroscience, Cancer, Metabolism, Developmental biology