710
Anti- SCAP Antibody | FNab07622
- SKU:
- 710-FNab07622-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SCAP Antibody | FNab07622 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity) .SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770) .
Immunogen: SREBF chaperone
synonyms: KIAA0199
Molecular weight (observed) : 140 kDa, 96 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC, FC, IF
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Research Area: Metabolism