Anti-SHH (Sonic Hedgehog) monoclonal Antibody | MB62407

Anti-SHH (Sonic Hedgehog) monoclonal Antibody | MB62407 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, WB

Application Range: WB: 1:2000, IF (1:100)

Background: SHH is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: sonic hedgehog

Molecular Weight: 27.6 kDa (Actual 22 kDa/55 kDa) (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS

Immunogen: Recombinant protein expressed in E.coli corresponding to amino acids 24-197 of human SHH

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A