710
Anti- SIRT5 Antibody | FNab07883
- SKU:
- 710-FNab07883-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SIRT5 Antibody | FNab07883 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693) . Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693) . Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062) . Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Immunogen: sirtuin (silent mating type information regulation 2 homolog) 5
synonyms: FLJ36950, SIR2 like protein 5, SIR2L5, SIRT5
Molecular weight (observed) : 33 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500
Research Area: Epigenetics, Metabolism