Anti- SLC25A33 Antibody | FNab07940

Anti- SLC25A33 Antibody | FNab07940 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081) . Transports preferentially uracil, thymine, and cytosine (deoxy) nucleoside di-and triphosphates by an antiport mechanism (PubMed:25320081) . Also transports guanine but not adenine (deoxy) nucleotides (PubMed:25320081) . Is inhibited strongly by pyridoxal 5'-phosphate, 4, 7-diphenyl-1, 10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081) . Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889) . Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519) . Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278) .

Immunogen: solute carrier family 25, member 33

synonyms: N/A

Molecular weight (observed) : 35-40 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Signal Transduction