Anti- SMAD7 Antibody | FNab07999

Anti- SMAD7 Antibody | FNab07999 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity) .

Immunogen: SMAD family member 7

synonyms: MADH7, MADH8

Molecular weight (observed) : 46 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, IF, WB, FC, IP

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology