710
Anti- SMC5 Antibody | FNab08019
- SKU:
- 710-FNab08019-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SMC5 Antibody | FNab08019 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541) .
Immunogen: structural maintenance of chromosomes 5
synonyms: KIAA0594, SMC5L1
Molecular weight (observed) : 120-130 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC, IF, WB
Recomended Dillution : WB: 1:500-1:2000
Research Area: Metabolism