710
Anti- SRGAP2 Antibody | FNab08225
- SKU:
- 710-FNab08225-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SRGAP2 Antibody | FNab08225 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Immunogen: SLIT-ROBO Rho GTPase activating protein 2
synonyms: ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3
Molecular weight (observed) : 130 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC, IP
Recomended Dillution : WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
Research Area: Signal Transduction