710
Anti- STAT3 Antibody | FNab08299
- SKU:
- 710-FNab08299-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- STAT3 Antibody | FNab08299 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214) . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214) . Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity) . May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580) . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
Immunogen: signal transducer and activator of transcription 3 (acute-phase response factor)
synonyms: Acute phase response factor, APRF, HIES, STAT3
Molecular weight (observed) : 88 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:1000-1:4000; IP: 1:1000-1:4000; IHC: 1:50-1:500; IF: 1:10-1:100
Research Area: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells