710
Anti- SYNE2 Antibody | FNab08436
- SKU:
- 710-FNab08436-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- SYNE2 Antibody | FNab08436 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.
Immunogen: spectrin repeat containing, nuclear envelope 2
synonyms: KIAA1011, NUA
Molecular weight (observed) : 55 kDa
Reactivity Species: Human
Tested Application: ELISA, WB, IHC, IF, IP
Recomended Dillution : WB: 1:500-1:1000
Research Area: Signal Transduction