Anti- TBC1D5 Antibody | FNab08515

Anti- TBC1D5 Antibody | FNab08515 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: May act as a GTPase-activating protein (GAP) for Rab family protein (s) . May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837) . Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) ; the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992) . May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492) .

Immunogen: TBC1 domain family, member 5

synonyms: KIAA0210

Molecular weight (observed) : 89 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF

Recomended Dillution : WB: 1:500-1:2400; IP: 1:200-1:1000 ; IHC: 1:20-1:200

Research Area: Cancer