Anti- TBCD Antibody | FNab08519

Anti- TBCD Antibody | FNab08519 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB) . Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.

Immunogen: tubulin folding cofactor D

synonyms: KIAA0988, SSD1, TFCD

Molecular weight (observed) : 130 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, FC

Recomended Dillution : WB: 1:500-1:2000; IP: 1:200-1:2000

Research Area: Cell Division and Proliferation, Metabolism