Anti- TCF7 Antibody | FNab08554

Anti- TCF7 Antibody | FNab08554 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4 (+) CD8 (+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Immunogen: transcription factor 7 (T-cell specific, HMG-box)

synonyms: TCF1

Molecular weight (observed) : 43 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Metabolism, Developmental biology