710
Anti- TRIM11 Antibody | FNab08967
- SKU:
- 710-FNab08967-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- TRIM11 Antibody | FNab08967 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Immunogen: tripartite motif-containing 11
synonyms: BIA1, Protein BIA1, RING finger protein 92, RNF92, TRIM11, tripartite motif containing 11
Molecular weight (observed) : 52 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IP
Recomended Dillution : WB: 1:200-1:1000; IHC: 1:20-1:200
Research Area: Epigenetics, Immunology, Metabolism