Anti-UGT1A1 Antibody | A2279

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate-binding site and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

A2279 | Anti-UGT1A1 Antibody DataSheet

Antibody Target: UGT1A1

Target Alternative Name: GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1, UGT1A1, EC 2.4.1.17, UGT1-01, UGT1*1, UGT1.1, UGT-1A

Tag Line: Affinity purified rabbit polyclonal antibody to detect UGT1A1 expression in mouse and rat samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Mouse, Rat

Immunogen Sequence: Recombinant fusion protein targeting a sequence around aa 1-200 of human UGT1A1 protein

Accession #: P22309

Gene ID: 54658

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3

Purification: Affinity purified

Application: Western Blotting Immunofluorescence (IF)

Positive Control:

Application And Usages: WB (1:500 - 1:2000), IF (1:50 - 1:200)

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE