710
Anti- UIMC1 Antibody | FNab09247
- SKU:
- 710-FNab09247-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- UIMC1 Antibody | FNab09247 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Ubiquitin-binding protein (PubMed:24627472) . Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36) . Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Immunogen: ubiquitin interaction motif containing 1
synonyms: BRCA1 A complex subunit RAP80, RAP80, Receptor associated protein 80, RXRIP110, UIMC1, X2HRIP110
Molecular weight (observed) : 97 kDa, 80 kDa, 71-75 kDa, 61 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, IP, WB
Recomended Dillution : WB: 1:200-1:1000; IP: 1:200-1:2000;IHC: 1:20-1:200; IF: 1:10-1:100
Research Area: Metabolism