Anti- UIMC1 Antibody | FNab09247

Anti- UIMC1 Antibody | FNab09247 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Ubiquitin-binding protein (PubMed:24627472) . Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36) . Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Immunogen: ubiquitin interaction motif containing 1

synonyms: BRCA1 A complex subunit RAP80, RAP80, Receptor associated protein 80, RXRIP110, UIMC1, X2HRIP110

Molecular weight (observed) : 97 kDa, 80 kDa, 71-75 kDa, 61 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, IP, WB

Recomended Dillution : WB: 1:200-1:1000; IP: 1：200-1：2000；IHC: 1：20-1：200; IF: 1：10-1：100

Research Area: Metabolism