710
Anti- URM1 Antibody | FNab09289
- SKU:
- 710-FNab09289-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- URM1 Antibody | FNab09289 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Acts as a sulfur carrier required for 2-thiolation of mcm (5) S (2) U at tRNA wobble positions of cytosolic tRNA (Lys), tRNA (Glu) and tRNA (Gln) . Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm (5) S (2) U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Immunogen: ubiquitin related modifier 1 homolog (S. cerevisiae)
synonyms: URM1, C9orf74
Molecular weight (observed) : 11 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF, IP
Recomended Dillution : WB: 1:500-1:5000; IHC:1:20-1:200
Research Area: Epigenetics, Metabolism