710
Anti- Uromodulin Antibody | FNab09294
- SKU:
- 710-FNab09294-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- Uromodulin Antibody | FNab09294 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Uromodulin, also known as THP (Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases. (PMID: 21654721)
Immunogen: uromodulin
synonyms: ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, UMOD, uromodulin
Molecular weight (observed) : 55-70 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IF, IHC
Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:500; IP: 1:200-1:2000
Research Area: N/A