710
Anti- VAMP8 Antibody | FNab09365
- SKU:
- 710-FNab09365-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- VAMP8 Antibody | FNab09365 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604) . Also required for dense-granule secretion in platelets (PubMed:12130530) . Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity) . Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity) . Involved in the homotypic fusion of early and late endosomes (By similarity) .
Immunogen: vesicle-associated membrane protein 8 (endobrevin)
synonyms: EDB, Endobrevin, VAMP 8, VAMP8
Molecular weight (observed) : 15 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:200-1:1000
Research Area: Neuroscience