Anti- WDR24 Antibody | FNab09488

Anti- WDR24 Antibody | FNab09488 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: As a component of the GATOR subcomplex GATOR2, functions as an activator of the amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:27166823) . Inhibits the GATOR1 subcomplex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (PubMed:23723238) . Functions downstream of and is regulated by amino acid sensors like SESN2 (PubMed:26449471, PubMed:26586190) . In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823) .

Immunogen: WD repeat domain 24

synonyms: C16orf21, DKFZp434F054, JFP7, WD repeat domain 24, WDR24

Molecular weight (observed) : 102 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200

Research Area: Cell Division and Proliferation