APC Anti-Human IL-17A Antibody[BL168] | E-AB-F1173E

APC Anti-Human IL-17A Antibody[BL168] | E-AB-F1173E | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: CTLA8, IL17,CTLA-8,IL 17A

Swissprot Code: Q16552

Application: ICFCM

Reactivity: Mouse

Host: Rat

Isotype: Rat IgG2a, λ

Research Areas: Cancer, Immunology

Backgroun: IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.

Concentration: N/A

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300, 1% BSA

Purification Method: N/A

Dilution: N/A

Clone: BL168

Conjugation: APC

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A