Apicidin | 1601

A potent, cell permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC₅₀ = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner.

Apicidin is a potent, cell permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deacetylase).

1601 | Apicidin DataSheet

Alternate Name/Synonyms: cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid

Appearance: Off-white solid

Formulation: N/A

CAS Number: 183506-66-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₄₉N₅O₆

Molecular Weight: 623.8

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (50 mg/ml) of EtOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A HDAC inhibitor

MDL Number: MFCD03452661

PubChem CID: 6918328

SMILES: CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC

InChi: InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1

InChi Key: JWOGUUIOCYMBPV-GMFLJSBRSA-N