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ApoA-1, human recombinant | 4693
- SKU:
- 26-4693-GEN
- Availability:
- Usually shipped in 5 working days
Description
ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the good cholesterol. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic Vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.
4693 | ApoA-1 human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Apolipoprotein A-I
Alternates names: APOA1, MGC117399, Apoa1, Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, apolipoprotein, apolipoproteins, MGC102525, Sep-1, Sep-2, Sep2, Human ApoA-1, ApoA-1, ApoA1, Apo A1, h-ApoA-1, rh-ApoA-1, recombinant human ApoA-1, ApoA1,recombinant ApoA-1, Apo, ApoA1, Apolipoprotein A-I, Apolipoprotein AI, Apolipoprotein
Taglines: A protein promoting cholesterol efflux from tissues to the liver
NCBI Gene ID #: 5764
NCBI Gene Symbol: PTN
Gene Source: Human
Accession #: P21246
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 20.6 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized with no additives
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A