APOC3 Antibody (C-term) [APR32499G]

APOC3 Antibody (C-term) [APR32499G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This APOC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70~99 amino acids from the C-term region of human APOC3.

Cellular Localisation: Secreted

Molecular Weight: 10852

Clone: Polyclonal

Gene Name: APOC3

Gene ID: 345

Function: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806) . Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806) . Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride- rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806) . Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806) . Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013) .

Summary: Tissue Location: Liver..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:2000

Synonyms: Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3