Apolipoprotein AI, Human Plasma | P1521

ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic Vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

P1521 | Apolipoprotein AI, Human Plasma DataSheet

Biomolecule/Target :

Synonyms: Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Apolipoprotein A-I(1-242)

Alternates names: Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Apolipoprotein A-I(1-242)

Taglines: A protein promoting cholesterol efflux from tissues to the liver

NCBI Gene ID #:

NCBI Gene Symbol: APOA1

Gene Source: Human

Accession #: P02647

Recombinant: False

Source: Human Plasma

Purity by SDS-PAGE: >95%

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level:

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Binding Capacity:

Unit Definition:

Molecular Weight: 28000

Concentration:

Appearance: Sterile Filtered colorless solution

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence:

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans