Apoptosis activator 2 | 2784

Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).

Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation.

2784 | Apoptosis activator 2 DataSheet

Alternate Name/Synonyms: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione

Appearance: Orange solid

Formulation: N/A

CAS Number: 79183-19-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₉Cl₂NO₂

Molecular Weight: 306.14

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An apoptosis activator

MDL Number: MFCD00141556

PubChem CID: 1901244

SMILES: C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

InChi: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2

InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N