Description
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation.
2784 | Apoptosis activator 2 DataSheet
Alternate Name/Synonyms: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Appearance: Orange solid
Formulation: N/A
CAS Number: 79183-19-0
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₉Cl₂NO₂
Molecular Weight: 306.14
Cell-Permeable?: Y
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An apoptosis activator
MDL Number: MFCD00141556
PubChem CID: 1901244
SMILES: C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
InChi: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |