APP (Amyloid beta precursor protein) monoclonal Antibody | MB62472

APP (Amyloid beta precursor protein) monoclonal Antibody | MB62472 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, WB

Application Range: WB 1:2000, IF 1:100

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: amyloid beta precursor protein

Molecular Weight: 85.1 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Immunogen: Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A