APP-C31 | Caspase 3 cleaved APP, C terminal fragment | AS21 4570

APP-C31 | Caspase 3 cleaved APP, C terminal fragment | AS21 4570 | Gentaur UK, US & Europe Distribution

Immunogen: Synthetic peptide corresponding to the N-terminal of human caspase 3-generated APP C-terminal 31 amino acids (aa 665-670) UniProt: P05067

Host: Rabbit

Conjugation: N/A

Clonality: N/A

Isotype: N/A

Purity: Serum. Contains 0.05 % sodium azide.

Format: Liquid

Tested Application: ELISA (ELISA), Immunolocalisation (IL), Western blot (WB)

Related Products: Collection of antibodies to proteins involved in Alzheimer's disease

Recommended Dilutions: 1::500 - 1: 1000 (IL), 1:1000-1:3000 (WB)

Molecular weight: 86, 9 | 100 kDa

Confirmed Reactivity: Human, Mouse, Rat

Predicted Reactivity: Species of your interest not listed? Contact us

Not reactive in: N/A

Additional Information: N/A

Background: The Alzheimer Amyloid Precursor Protein (APP) is a transmembrane protein whose abnormal processing is associated with the pathogenesis of Alzheimer's disease. APP695 lacking the protease inhibitor domain is the predominant form in neuronal tissues. APP695 is cleaved by caspases into the 664-residue amino (N) -terminal fragment that lacks the carboxyl C-terminal 31-residues (APP-C31) and the 31-residues C-terminal fragment (APP-C31) . Both fragments might be potent inducers of neuronal apoptosis. An antibody (named ACT1) against the N-terminus of caspase 3-generated APP C-terminal 31 aa of human APP695 (APP-C31 ) was raised in rabbit.

Reconstitution: For reconstitution add µl, of sterile water

Storage: Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathology, Alzheimer's disease