APP Delta C31 (C-terminal) | AS21 4571

APP Delta C31 (C-terminal) | AS21 4571 | Gentaur UK, US & Europe Distribution

Immunogen: KLH-conjugated synthetic peptide corresponding to the C-terminal of the caspase 3-cleaved human APP (aa 658-664 of human APP695) UniProt: P05067

Host: Rabbit

Conjugation: N/A

Clonality: N/A

Isotype: N/A

Purity: Serum. Contains 0.05 % sodium azide.

Format: Liquid

Tested Application: ELISA (ELISA), Immunolocalisation (IL), Western blot (WB)

Related Products: Collection of antibodies to proteins involved in Alzheimer's disease

Recommended Dilutions: 1:500 - 1: 1000 (Immunocytochemistry), 1:1000 - 1: 3000 (WB)

Molecular weight: 86, 9 | 96 kDa

Confirmed Reactivity: Human, mouse, rat

Predicted Reactivity: Species of your interest not listed? Contact us

Not reactive in: N/A

Additional Information: N/A

Background: The Alzheimer amyloid precursor protein (APP) is a transmembrane protein whose abnormal processing is associated with the pathogenesis of Alzheimer's disease. APP695 lacking the protease inhibitor domain is the predominant form in neuronal tissues. APP695 is cleaved by caspases into the 664-residue amino (N) -terminal fragment that lacks the carboxyl C-terminal 31-residues (APP delataC31) and the 31-residues C-terminal fragment (APP-C31) . APP delta C31 potentially plays pathophysiological roles in neuronal death.

Reconstitution: N/A

Storage: Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathology, Alzheimer's disease