Apremilast | 2352

Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.

Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM).

2352 | Apremilast DataSheet

Alternate Name/Synonyms: N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Appearance: White solid

Formulation: N/A

CAS Number: 608141-41-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₄N₂O₇S

Molecular Weight: 460.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (80 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent PDE4 (phosphodiesterase 4) inhibitor

MDL Number: N/A

PubChem CID: 11561674

SMILES: CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

InChi: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChi Key: IMOZEMNVLZVGJZ-QGZVFWFLSA-N