Description
Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM).
Alternate Name/Synonyms: N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
Appearance: White solid
Formulation: N/A
CAS Number: 608141-41-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₄N₂O₇S
Molecular Weight: 460.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (80 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent PDE4 (phosphodiesterase 4) inhibitor
MDL Number: N/A
PubChem CID: 11561674
SMILES: CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
InChi: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChi Key: IMOZEMNVLZVGJZ-QGZVFWFLSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |