AQP12 (P265) polyclonal Antibody | BS3075

AQP12 (P265) polyclonal Antibody | BS3075 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO) . No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: AQP12 (P265) pAb detects endogenous levels of AQP12 protein.

Molecular Weight: ~ 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Aquaporin-12A; AQP-12; AQP12A; AQP12; AQPX2; Aquaporin-12B; AQP-12B; AQP12B

Immunogen: Synthetic peptide, corresponding to amino acids 230-296 of Human AQP12.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A