AR-β2 (phospho-S346) polyclonal Antibody | BS4652

AR-β2 (phospho-S346) polyclonal Antibody | BS4652 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca (V) 1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-AR-β2 (S346) polyclonal Antibody detects endogenous levels of AR-β2 protein only when phosphorylated at Ser346.

Molecular Weight: ~ 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR; Beta-2 adrenergic receptor; ARβ2

Immunogen: Synthetic phosphopeptide derived from human AR-β2 around the phosphorylation site of Serine 346.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Protein Kinase C Signaling,Hypoxia Signaling,Translational Contral elF4 and p70 S6 Kinase,Inhibition of Apoptosis,Insulin &Glucose Signaling,MAPK Erk in Growth and Differentiation Pathway,Mitochondrial Control of Apoptosis,MTOR signaling,ErbB HER Signaling,