ARG2 Polyclonal Antibody | E-AB-40108

ARG2 Polyclonal Antibody | E-AB-40108 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ARG2, ARGI2, Arginase II mitochondrial, Arginase type II, Arginase-2, arginase-2, mitochondrial, Kidney arginase, Kidney type arginase, Kidney-type arginase, L arginine amidinohydrolase, L arginine ureahydrolase, mitochondrial, Non hepatic arginase, Non-hepatic arginase, Nonhepatic arginase, Type II arginase

Application: IHC

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Metabolism, Signaling transduction

Background: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082).

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant human Arginase-2 protein

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: IHC 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A