ARQ-531 | B2790

ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

B2790 | ARQ-531 DataSheet

Alternate Name/Synonyms: (2-chloro-4-phenoxyphenyl)-[4-[[(3R,6S)-6-(hydroxymethyl)oxan-3-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone

Appearance: Crystalline solid

Formulation:

CAS Number: 2095393-15-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₃ClN₄O₄

Molecular Weight: 478.93

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Bruton's tyrosine kinase (BTK) inhibitor

MDL Number:

PubChem CID: 129045720

SMILES: C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO

InChi: C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO

InChi Key: JSFCZQSJQXFJDS-QAPCUYQASA-N