Description
ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.
ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.
Alternate Name/Synonyms: (2-chloro-4-phenoxyphenyl)-[4-[[(3R,6S)-6-(hydroxymethyl)oxan-3-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone
Appearance: Crystalline solid
Formulation:
CAS Number: 2095393-15-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₃ClN₄O₄
Molecular Weight: 478.93
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A Bruton's tyrosine kinase (BTK) inhibitor
MDL Number:
PubChem CID: 129045720
SMILES: C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO
InChi: C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO
InChi Key: JSFCZQSJQXFJDS-QAPCUYQASA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |