AS-252424 | B1611

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50=230 nM. In a mouse model of peritonitis, PI 3-Kᵧ this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.

AS-252424 is a potent inhibitor of PI3K

B1611 | AS-252424 DataSheet

Alternate Name/Synonyms: AS-252424; AS 252424; AS252424; 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; PI3Kg/CKII Inhibitor

Appearance: Solid

Formulation: N/A

CAS Number: 900515-16-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₈FNO₄S

Molecular Weight: 305.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PI3Kg/CKII Inhibitor

MDL Number: MFCD11045281

PubChem CID: 16757575

SMILES: C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3

InChi: 1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+

InChi Key: OYYVWNDMOQPMGE-WUXMJOGZSA-N