Description
AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50=230 nM. In a mouse model of peritonitis, PI 3-Kᵧ this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.
AS-252424 is a potent inhibitor of PI3K
Alternate Name/Synonyms: AS-252424; AS 252424; AS252424; 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; PI3Kg/CKII Inhibitor
Appearance: Solid
Formulation: N/A
CAS Number: 900515-16-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₈FNO₄S
Molecular Weight: 305.3
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A PI3Kg/CKII Inhibitor
MDL Number: MFCD11045281
PubChem CID: 16757575
SMILES: C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3
InChi: 1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
InChi Key: OYYVWNDMOQPMGE-WUXMJOGZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |